Techniques in Vascular & Interventional Radiology
Volume 9, Issue 1 , Pages 12-18 , March 2006

New Treatments for Uterine Fibroids

  • Gary Siskin, MD

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Department of Radiology, Albany Medical Center, 47 New Scotland Avenue, MC-113, Albany, NY 12208.

References 

  1. Walker CL, Stewart EA. Uterine fibroids: The elephant in the room. Science. 2005;308:1589–1592
  2. Munro MG. Management of leiomyomas: Is there a panacea in Pandora’s box?. Fertil Steril. 2006;85:40–43
  3. Bergamini V, Ghezzi F, Cromi A, et al. Laparoscopic radiofrequency thermal ablation: A new approach to symptomatic uterine myomas. Am J Obstet Gynecol. 2005;192:768–773
  4. Milic A, Asch MR, Hawrylyshyn PA, et al. Laparoscopic ultrasound-guided radiofrequency ablation of uterine fibroids. Cardiovasc Intervent Radiol. 2006;29:694–698
  5. Nisolle M, Smets M, Malvaux V, et al. Laparoscopic myolysis with the neodymium-ytrium aluminum garnet laser. Int J Gynaecol Surg. 1993;9:95–99
  6. Law P, Gedroyc WMW, Regan L. Magnetic-resonance guided percutaneous laser ablation of uterine fibroids. Lancet. 1999;354:2049–2050
  7. Law P, Gedroyc WMW, Regan L. Magnetic resonance-guided percutaneous laser ablation of uterine fibroids. J Magn Reson Imaging. 2000;12:565–570
  8. Parker DL, Smith V, Sheldon P, et al. Temperature distribution measurements in two dimensional NMR imaging. Med Phys. 1983;10:321–325
  9. Law P, Regan L. Interstitial thermo-ablation under MRI guidance for the treatment of fibroids. Curr Opin Obstet Gynecol. 2000;12:277–282
  10. Hindley JT, Law PA, Hickey M, et al. Clinical outcomes following percutaneous magnetic resonance image guided laser ablation of symptomatic uterine fibroids. Hum Reprod. 2002;17:2737–2741
  11. Dohi M, Harada J, Mogami T, et al. MR-guided transvaginal cryotherapy of uterine fibroids with a horizontal open MRI system: Initial experience. Radiat Med. 2004;22:391–397
  12. Tacke J, Adam G, Haage P, et al. MR-guided percutaneous cryotherapy of the liver: In-vivo evaluation with histologic correlation in an animal model. J Magn Reson Imaging. 2001;13:50–56
  13. Rubinsky B, Lee CY, Bastacky J, et al. The process of freezing and the mechanism of damage during hepatic cryosurgery. Cryobiology. 1990;27:85–97
  14. Bischof JC, Fahssi WM, Smith D, et al. A parametric study of freezing injury in ELT-3 uterine leiomyoma tumour cells. Hum Reprod. 2001;16:340–348
  15. Rupp CC, Nagel TC, Swanlund DK, et al. Cryothermic and hyperthermic treatments of human leiomyoma and adjacent myometrium and their implications for laparoscopic surgery. J Am Assoc Gynecol Laparosc. 2003;10:90–98
  16. Olive DL, Rutherford T, Zreik T, et al. Cryomyolysis in the conservative treatment of uterine fibroids. J Am Assoc Gynecol Laparosc. 1996;3(suppl):S36
  17. Zreik TG, Rutherford TJ, Palter SF, et al. Cryomyolysis, a new procedure for the conservative treatment of uterine fibroids. J Am Assoc Gynecol Laparosc. 1998;5:33–38
  18. Ciavattini A, Tsiroglou D, Piccioni M, et al. Laparoscopic cryomyolysis (An alternative to myomectomy in patients with symptomatic fibroids). Surg Endosc. 2004;18:1785–1788
  19. Zupi E, Piredda A, Marconi D, et al. Directed laparoscopic cryomyolysis: A possible alterantive to myomectomy and/or hysterectomy for symptomatic leiomyomas. Am J Obstet Gynecol. 2004;190:639–643
  20. Zupi E, Marconi D, Sbracia M, et al. Directed laparoscopic cryomyolysis for symptomatic leiomyomata: One-year follow-up. J Min Inv Gynecol. 2005;12:343–346
  21. Exacoustos C, Zupi E, Marconi D, et al. Ultrasound-assisted, laparoscopic cryomyolysis: Two- and three-dimensional findings before, during and after treatment. Ultrasound Obstet Gynecol. 2005;25:393–400
  22. Sewell PE, Arriola RM, Robinette L, et al. Real-time I-MR-guided cryoablation of uterine fibroids. J Vasc Interv Radiol. 2001;12:891–893
  23. Cowan BD, Sewell PE, Howard JC, et al. Interventional magnetic resonance imaging cryotherapy of uterine fibroid tumors: Preliminary observation. Am J Obstet Gynecol. 2002;186:1183–1187
  24. Sakuhara Y, Shimizu T, Kodama Y, et al. Magnetic resonance-guided percutaneous cryoablation of uterine fibroids: Early clinical experiences. Cardiovasc Intervent Radiol. 2006;29:552–558
  25. Pelage JP, Guaou NG, Jha RC, et al. Uterine fibroid tumors: Long-term MR imaging outcome after embolization. Radiology. 2004;230:803–809
  26. Lynn JG, Zwemer RL, Chick AJ, et al. A new method for the generation and use of focused ultrasound in experimental biology. J Gen Physiol. 1942;26:179–183
  27. Kennedy JE, Haar GR, Cranston D. High intensity focused ultrasound: Surgery of the future?. Br J Radiol. 2003;76:590–599
  28. Tempany CMC, Stewart EA, McDannold N, et al. MR-imaging-guided focused ultrasound surgery of uterine leiomyomas: A feasibility study. Radiology. 2003;226:897–905
  29. Hynynen K, Vykhodtseva NI, Chung A, et al. Thermal effects of focused ultrasound on the brain: Determination with MR imaging. Radiology. 1997;204:247–253
  30. Chung A, Jolesz FA, Hynynen K. Thermal dosimetry of a focused ultrasound beam in vivo by MRI. Med Phys. 1999;26:2017–2026
  31. Vaezy S, Fujimoto VY, Walker C, et al. Treatment of uterine fibroid tumors in a nude mouse model using high-intensity focused ultrasound. Am J Obstet Gynecol. 2000;183:6–11
  32. Stewart EA, Gedroyc WMW, Tempany CMC, et al. Focused ultrasound treatment of uterine fibroid tumors: Safety and feasibility of a noninvasive thermoablative technique. Am J Obstet Gynecol. 2003;189:48–54
  33. Hindley J, Gedroyc WMW, Regan L, et al. MRI guidance of focused ultrasound therapy of uterine fibroids: Early results. AJR. 2004;183:1713–1719
  34. Stwart EA, Rabinovici J, Tempany CMC, et al. Clinical outcomes of focused ultrasound surgery for the treatment of uterine fibroids. Fertil Steril. 2004;85:22–29
  35. Hald K, Langebrekke A, Klow NE, et al. Laparoscopic occlusion of uterine vessels for the treatment of symptomatic uterine fibroids: Initial experience and comparison to uterine artery embolization. Am J Obstet Gynecol. 2004;190:37–43
  36. Liu WM, Ng HT, Wu YC, et al. Laparoscopic bipolar coagulation of uterine vessels: A new method for treating symptomatic uterine fibroids. Fertil Steril. 2001;75:417–422
  37. Istre O, Hald K, Qvigstad E. Multiple myomas treated with a temporary, noninvasive Doppler-directed transvaginal uterine artery clamp. J Am Assoc Gynecol Laparosc. 2004;11:273–276
  38. Murphy AA, Kettel LM, Morales AJ, et al. Regression of uterine leiomyomata in response to the antiprogesterone RU 486. J Clin Endocrinol Metab. 1993;76:513–517
  39. Eisinger SH, Bonfiglio T, Fiscella K, et al. Twelve month safety and efficacy of low-dose mifepristone for uterine myomas. J Minim Invasive Gynecol. 2005;12:227–233
  40. Reinsch RC, Murphy AA, Morales AJ, et al. The effects of RU 486 and leuprolide acetate on uterine artery blood flow in the fibroid uterus: A prospective, randomized study. Am J Obstet Gynecol. 1994;170:1623–1628
  41. Chwalisz K, Perez MC, DeManno D, et al. Selective progresterone receptor modulator development and use in the treatment of leiomyomata and endometriosis. Endocrine Reviews. 2005;26:423–438
  42. Murphy AA, Kettel LM, Morales AJ, et al. Endometrial effects of long-term low-dose administration of RU-486. Fertil Steril. 1995;63:761–766
  43. Eisinger SH, Meldrum S, Fiscella K, et al. Low-dose mifepristone for uterine leiomyomata. Obstet Gynecol. 2003;101:243–250
  44. Brandon DD, Bethea CL, Strawn EY, et al. Progesterone receptor messenger ribonucleic acid and protein are overexpressed in human uterine leiomyomas. Am J Obstet Gyncol. 1993;169:78–85
  45. Harrison-Woolrych ML, Charnock-Jones DS, Smith SK. Quantification of messenger ribonucleic acid for epidermal growth factor in human myometrium and leiomyomata using reverse transcriptase polymerase chain reaction. J Clin Endocrinol Metab. 1994;78:1179–1184
  46. Maruo T, Matsuo H, Samoto T, et al. Effects of progesterone on uterine leiomyoma growth and apoptosis. Steroids. 2000;65:585–592
  47. Maruo T, Matsuo H, Shimomura Y, et al. Effects of progesterone on growth factor expression in human uterine leiomyoma. Steroids. 2003;68:817–824
  48. Bachmann G. Expanding treatment options for women with symptomatic uterine leiomyomas: Timely medical breakthroughs. Fertil Steril. 2006;85:46–47
  49. Wang J, Ohara N, Wang Z, et al. A novel selective progesterone receptor modulator asoprisnil (J867) downregulates the expression of EGF, IGF-I, TGFbeta3, and their receptors in cultured uterine leiomyoma cells. Hum Reprod. 2006;21:1869–1877
  50. Chwalisz K, DeManno D, Garg R, et al. Therapeutic potential for the selective progesterone receptor modulator asoprisnil in the treatment of leiomyomata. Semin Reprod Med. 2004;22:113–119
  51. Chwalisz K, Elger W, McCrary K, et al. Reversible suppression of menstruation in normal women irrespective of the effect on ovulation with the noval selective progesterone receptor modulator (SPRM) J867. J Soc Gynecol Investig. 2002;9(suppl):abstract 49
  52. Chwalisz K, Parker L, Williamson S. Treatment of uterine leiomyomas with the novel selective progesterone receptor modulator (SPRM). J Soc Gynecol Investig. 2003;10:abstract 301A
  53. Young SL, Al-Hendy A, Copland JA. Potential nonhormonal therapeutics for medical treatment of leiomyomas. Semin Reprod Med. 2004;22:121–130

PII: S1089-2516(06)00027-8

doi: 10.1053/j.tvir.2006.08.004

Techniques in Vascular & Interventional Radiology
Volume 9, Issue 1 , Pages 12-18 , March 2006

Article Tools